I’ve been hitting an odd problem on my Vista desktop machine for quite some time now where an error messaging stating that EXCEL.EXE "is not a valid Win32 application" when trying to launch Excel if I’ve been running for a while (e.g. several days or a week).  I looked on the net and in Microsoft’s forums (still in newsgroups - what a pain) and couldn’t find a solution.  Turns out Microsoft engineers have been working on a fix for a while and they’ve finally released it.  Check out InfoWorld’s article on this.

I can’t wait for this to be released.  I had to reboot just yesterday due to this problem.